nick-sirianni-philadelphia-eagles
Imagn Images

The NFL playoff picture will finalize after the NFL Week 18 schedule. The top seeds in both the AFC and NFC are still at stake, as is who is going to take the NFC South and AFC North title and the playoff spot that comes with it. The winner of the Seattle vs. San Francisco game will get the top seed in the NFC, while Denver is one win away from being the top seed in the AFC. If the Broncos falter against the Los Angeles Chargers, New England can take top honors with a win over Miami.

There are a number of important matchups on the Week 18 NFL schedule, including two on Saturday with Panthers vs. Buccaneers (-3) and Seahawks vs. 49ers (+2.5). The rest of the slate is Sunday, including Colts vs. Texans (-10.5), Packers vs. Vikings (-10), Lions vs. Bears (-3), Chargers vs. Broncos (-13.5), Dolphins vs. Patriots (-11.5) and Commanders vs. Eagles (-4). The Ravens (-3.5) face the Steelers on 'Sunday Night Football' in Pittsburgh with the AFC North on the line. 

Before locking in any Week 18 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine's proven computer model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model entered Week 18 on a 53-37 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

Now, the model has scoured the Week 18 NFL odds and locked in five confident NFL best bets. If you successfully parlay its picks, you'd be looking at a massive payout of over 25-1. You can only see the model's Week 18 NFL picks at SportsLine.

Top Week 18 NFL picks

After simulating every game 10,000 times, the model is high on the Philadelphia Eagles (-4, 39) to cover against the Commanders on Sunday at 4:25 p.m. ET. Bet our Eagles vs. Commanders SGP at DraftKings below, and see our 25-1 Week 18 NFL parlay at SportsLine.

The Eagles plan to sit some starters as they look to rest for the playoffs. Despite that, they are still incentivized to win the gaame. A win could get them as high as the No. 2 seed, giving them a chance at more possible home games in the postseason. Tanner McKee is a capable backup at quarterback if the Eagles sit Jalen Hurts for some or all of the game, and Philly is still well-equipped to win at home against a Washington team that has been decimated by injuries. 

The model has Philadelphia winning by double digits as the Eagles cover more than 60% of the time. See which other NFL parlay picks to make here.

How to make Week 18 NFL parlays

The model also jumped on four other NFL matchups where it says the line is way off, including backing an underdog that it says will easily cover. You can only see the model's Week 18 NFL best bets and NFL parlay at SportsLine.

What are the model's top Week 18 NFL picks, and which NFL matchups should you target for an epic 25-1 payout? Visit SportsLine now to see the Week 18 NFL best bets from a model on a 53-37 run on top-rated picks, and find out.